colon cancer trials 2019

Location: 741 locations, This phase III trial studies combination chemotherapy and atezolizumab to see how well it works compared with combination chemotherapy alone in treating patients with stage III colon cancer and deficient deoxyribonucleic acid (DNA) mismatch repair. Researchers at Memorial Sloan Kettering are exploring new therapies and diagnostic tools for colon and rectal cancer. The study is being conducted in patients with several types of refractory cancers including those at the surface of the skin (breast, squamous cell, head and neck) and tumors within the body such (pancreatic, colon, liver, lung, etc.). When trastuzumab attaches to HER2 receptors, the signals that tell the cells to grow are blocked and the cancer cell may be marked for destruction by the body’s immune system. Studying vitamin D-bound sites and vitamin D-regulated genes may help doctors understand how cholecalciferol works in treating colorectal cancer and help doctors plan better treatment. Transanal mesorectal excision with laparoscopic assistance is a procedure that combines standard laparoscopy, or multiple small abdominal incisions, with surgery through the anus in order to remove rectal cancer, and it may work better in treating patients with rectal cancer. In the second part of this study, participants are randomly assigned to either Cohort B or Cohort C. Participants in Cohort B will receive tucatinib and trastuzumab. Vitamin D3 helps the body use calcium and phosphorus to make strong bones and teeth. After completing the questions, you … The study is composed of a safety run-in and an exploratory part. The clinical trials on this list are for colorectal cancer. Antibodies that block PD-1 can potentially prevent PD-1 from shutting down the immune system, thus potentially allowing immune cells to recognize and destroy cancer cells. Odontogenic malignant tumors 22. Adrenal cortical tumors (closed to accrual 06 / 27 / 2018) 32. Location: 21 locations, This phase II / III trial studies how well circulating tumor deoxyribonucleic acid (ctDNA) testing in the blood works to identify patients with stage IIA colon cancer who might benefit from additional treatment with chemotherapy after surgery. Location: 3 locations, This study is designed to primarily evaluate the safety and efficacy of U3-1402 in participants with advanced or metastatic colorectal cancer (CRC) who have received at least 2 prior lines of therapy and will explore clinical benefit according to human epidermal growth factor receptor 3 (HER3) tumor expression level in otherwise refractory tumors. Encorafenib, binimetinib and cetuximab target different parts of this important signaling pathway in tumor cells with this mutation and may slow down their growth and communication. PD-L1 amplified tumors 50. Location: 26 locations, This trial studies how well the drug tucatinib works when given with trastuzumab and when given by itself. Search for closest city to find more detailed information on a research study in your … Location: 22 locations, This is a multi-center, open-label, first-in-human Phase 1 study evaluating the anti-programmed death receptor 1 (anti-PD-1) antibody dostarlimab (also known as TSR-042) n participants with advanced solid tumors who have limited available treatment options. Several decades ago, colorectal cancer was infrequently diagnosed. Drugs used in chemotherapy, such as irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Location: 28 locations, This is an open-label, multicenter, multinational, Phase 2 basket study exploring the efficacy and safety of neratinib as monotherapy or in combination with other therapies in participants with HER (EGFR, HER2) mutation-positive solid tumors. Location: 3 locations, This phase II trial studies how well TAS-102 and oxaliplatin work in treating patients with stage IV colon cancer. One exploratory single-agent atezolizumab (SAA) cohort may also be enrolled with CRPC subjects. Doctors recommend certain screening tests for healthy people with no signs or symptoms in order to look for signs of colon cancer or noncancerous colon polyps. Location: 5 locations, This phase II trial studies how well TAS-102, irinotecan, and bevacizumab work in treating patients with pre-treated colorectal cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable). Clinical trials are research studies that involve people. The participants in this trial have HER2-positive (HER2+) metastatic colorectal cancer (mCRC). Treatment-emergent small-cell neuroendocrine prostate cancer (t-SCNC) About 606,880 Americans are expected to die of cancer in 2019 (Table 1), which translates to about 1,660 deaths per day. Location: 901 locations, This phase II trial studies how well savolitinib works in treating patients with MET amplified colorectal cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable). Non-epithelial tumors of the ovary: A) Germ cell tumor of ovary B) Mullerian mixed tumor and adenosarcoma (closed to accrual 03 / 30 / 2018) 14. Location: 6 locations, This is a Phase 1a / 1b, open-label, multicenter, global, dose-escalation study designed to evaluate the safety, tolerability, immune response, and pharmacokinetics of RO7198457 as a single agent and in combination with atezolizumab (MPDL3280A, an engineered anti-programmed death-ligand 1 [anti-PD-L1] antibody). This is genetic material unique to the cancer that may be present in the blood stream and can be identified through a ctDNA blood test. Location: 16 locations, This study will evaluate the safety profile, tolerability, PK, PD, and preliminary efficacy of BMS-813160 alone or in combination with either chemotherapy or nivolumab in participants with metastatic colorectal and pancreatic cancers. Part 2 of the study will further evaluate the RP2D in 3 distinct tumor cohorts of approximately 12 subjects each. Extrahepatic cholangiocarcinoma and bile duct tumors (closed to accrual 03 / 20 / 2018) 11. It’s all due to a Phase I clinical trial at MD Anderson, and a doctor’s willingness to experiment with a drug that was originally used only to treat advanced melanoma. Physically and emotionally drained from chemotherapy, she was unable to care for her family the way … Clinical trials are research studies that involve people. Pheochromocytoma, malignant (closed to accrual) 25. The participants in this trial have HER2-positive (HER2+) metastatic colorectal cancer (mCRC). Adenocarcinoma with variants of GU system (excluding prostate cancer) (closed to accrual 07 / 27 / 2018) 21. Not Otherwise Categorized (NOC) Rare Tumors [To obtain permission to enroll in the NOC cohort, contact: S1609SC@swog.org] (closed to accrual 03 / 15 / 2019) 34. All trials on the list are supported by NCI. Undifferentiated carcinoma of gastrointestinal (GI) tract 5. The study will be conducted in 2 parts: with Part 1 consisting of dose escalation and Part 2 dose expansion. When trastuzumab attaches to HER2 receptors, the signals that tell the cells to grow are blocked and the cancer cell may be marked for destruction by the body’s immune system. Location: 911 locations, This randomized phase II trial studies how well trastuzumab and pertuzumab work compared to cetuximab and irinotecan hydrochloride in treating patients with HER2 / neu amplified colorectal cancer that has spread from where it started to other places in the body (advanced / metastatic) and cannot be removed by surgery. Endometrial carcinosarcoma (malignant mixed Mullerian tumors) (closed to accrual) 45. Screening has been shown to reduce your risk of dying of colon cancer.Doctors generally recommend that people with an average risk of colon cancer begin screening around ag… Location: 3 locations, The purpose of this phase 2 study is to evaluate the efficacy and safety of NIR178 in combination with PDR001 in multiple solid tumors and diffuse large B-cell lymphoma (DLBCL) and further explore schedule variations of NIR178 to optimize immune activation through inhibition of A2aR. It is not yet known whether giving high-dose vitamin D3 in addition to chemotherapy and bevacizumab would extend patients time without disease compared to the usual approach (chemotherapy and bevacizumab). The COBRA trial, which opened to accrual in December 2019, is expected to enroll over 1,400 patients who have resected stage IIA colon cancer that is considered low-risk and would not … Milos Miljkovic, M.D., M.Sc., Assistant Research Physician in the Lymphoid Malignancies Branch, is leading a study of a 4-drug combination treatment strategy using romidepsin, oral 5 … In the first part of this study, participants enrolled into Cohort A and received both tucatinib and trastuzumab. provides estimated new cancer cases in 2019 by state. It is not yet known whether giving additional treatment with chemotherapy after surgery to patients who test positive for ctDNA and are at low risk for cancer recurrence would extend their time without disease compared to the usual approach (active surveillance). VEGF is a substance made by cells that helps the formation of new blood vessels. Location: 684 locations, This is a Phase 1 / 2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antineoplastic activity of pralsetinib (BLU-667) administered orally in patients with medullary thyroid cancer, RET-altered NSCLC and other RET-altered solid tumors. Bevacizumab is a monoclonal antibody that binds to vascular endothelial growth factor (VEGF). Trials give researchers, scientists, and clinical providers … Small cell carcinoma of the ovary, hypercalcemic type 49. Rare pancreatic tumors including acinar cell carcinoma, mucinous cystadenocarcinoma or serous cystadenocarcinoma. Dose escalation will be based on ascending weight-based dose levels (DLs) of dostarlimab and will continue until the maximum tolerated dose (MTD) is reached or may be stopped at any dose level up to the highest dose of 20 milligrams per kilograms (mg / kg) based on emerging safety and PK / PDy data. Location: 15 locations, This is a Phase 1 / 2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antineoplastic activity of pralsetinib (BLU-667) administered orally in patients with medullary thyroid cancer, RET-altered NSCLC and other RET-altered solid tumors. When this mutation is present, it switches on pathway called the MAPK pathway which stimulates cell division and leads to uncontrolled cell growth. It works by attaching to and blocking a molecule called PD-1. Vitamin D3 may also modulate the immune system and is being studied in the prevention and treatment of some types of cancer. Growth factor antagonists, such as regorafenib, may interfere with the growth factor and stop the tumor from growing. This year it’s estimated that more than 100,000 new cases of colon cancer and an estimated 44,180 new cases of rectal cancer will be diagnosed in the U.S., according to the American Cancer … VEGF is a substance made by cells that helps the formation of new blood vessels. Giving trastuzumab and pertuzumab may work better compared to cetuximab and irinotecan hydrochloride in treating patients with colorectal cancer. It is the second leading cause of cancer death among men and women in the U.S, and an estimated one in 20 people will … Bevacizumab is a monoclonal antibody that binds to vascular endothelial growth factor (VEGF). I.T. Colorectal cancer is a cancer that starts in the colon or the rectum. Colorectal Cancer Facts& Figures 2017-2019 1 Colorectal Cancer Basic Facts What is colorectal cancer? Cabozantinib-s-malate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. The clinical trials on this list are for colon cancer treatment. Encorafenib in combination with binimetinib and cetuximab may target the BRAF V600E-mutation in colorectal cancer. In Part A, the treatment will be given to participants every 3 weeks (3-week cycles). Location: 11 locations, This clinical trial is a Phase 1 / 2, open-label, sequential-group, dose-escalation and cohort expansion study to determine the safety and preliminary anti-tumor activity of FLX475 as monotherapy and in combination with pembrolizumab. Clinical trials … Participants in Cohort C will receive tucatinib. Vitamin D3 helps the body use calcium and phosphorus to make strong bones and teeth. Location: 23 locations, This is an open-label, multicenter, global Phase 2 basket study of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor an NTRK1 / 2 / 3, ROS1, or ALK gene fusion. J Clin Oncol. Due to the nature of this study design, some tumor cohorts may complete enrollment earlier than others. Location: 901 locations, This phase II trial studies how well savolitinib works in treating patients with MET amplified colorectal cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable). Drugs used in combination chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. If you qualify, your treatment team can recommend one of our clinical trials … Colorectal cancer … In 2018, it was the third-most common diagnosed cancer among both men and women in the U.S., and data indicate that younger adults are increasingly being diagnosed with it.. To help develop new treatments and preventive measures to stop the disease, Cancer Research … MEK inhibitor binimetinib 3. Included tumor types (a, b) and regional distribution (c) of clinical PD-1 / PD-L1 and CAR T cell trials in 2019.ClinicalTrials.gov was searched for “pd-l1” OR “pd-1” OR “programmed death ligand” OR “car t cell” OR “chimeric antigen receptor”. Cell tumor of the testes and extragonadal germ tumors: A) Seminoma and testicular sex cord cancer B) Non-seminomatous tumor C) Teratoma with malignant transformation (closed to accrual) 17. Nov. 25, 2019 — Two genes that appear to help stem cells in the intestine burn dietary fat may play a role in colon cancer, according to a new study. Savolitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Treatment with panitumumab may interfere with the ability of tumor cells to grow and spread. High-grade neuroendocrine carcinoma (pancreatic neuroendocrine tumor [PNET] should be enrolled in Cohort 22; prostatic neuroendocrine carcinomas should be enrolled into Cohort 52). In Part 1 of the study, subjects will be enrolled in sequential cohorts treated with successively higher doses of FLX475 as monotherapy or in combination with pembrolizumab. In the first part of this study, participants enrolled into Cohort A and received both tucatinib and trastuzumab. Written by Monica Beyer on May 5, 2019 — Fact checked by Carolyn Robertson. Location: 2 locations, This early phase I trial studies how well heated intra-peritoneal chemotherapy with doxorubicin and cisplatin work for the treatment of abdominal or pelvic tumors that can be removed by surgery (resectable), does not respond to treatment (refractory), or has come back (recurrent). Nivolumab is an anti-PD-1 antibody. Clear cell cervical cancer 43. Gallbladder cancer 48. Adenoid cystic carcinoma (closed to accrual 02 / 06 / 2018) 35. Answering a simple series of questions allows us to find relevant trials that fit your needs. ctDNA are small pieces of genetic materials (DNA) that are shed by tumors into the blood. Giving combination chemotherapy with atezolizumab may work better than combination chemotherapy alone in treating patients with colon cancer. This trial enrolls participants for the following cohorts based on condition: 1. Adenocarcinoma with variants of small intestine (closed to accrual 05 / 10 / 2018) 6. In Part 2 of the study, subjects will be initially enrolled in Stage 1 of parallel expansion cohorts of FLX475 as monotherapy or in combination with pembrolizumab. Getting started with the Colorectal Cancer Alliance Clinical Trial Finder is easy! The Colon Cancer Foundation and the American Cancer Society have joined forces on an initiative called 80% in Every Community, which challenges you to take a stand against one of the most preventable forms of cancer – colorectal cancer – by getting screened, choosing a healthy way of eating and being physically active. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Cancer is a disease characterized by the unchecked division and survival of abnormal cells. Immunotherapy with monoclonal antibodies, such as panitumumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread Giving cabozantinib-s-malate with panitumumab may work better in treating patients with colorectal cancer. Paraganglioma (closed to accrual 11 / 29 / 2018) 26. It involves the infusion of a heated chemotherapy solution that circulates into the abdominal cavity. Gastrointestinal stromal tumor (GIST) (closed to accrual 09 / 26 / 2018) 38. Location: 878 locations, This randomized phase II trial studies how well trastuzumab and pertuzumab work compared to cetuximab and irinotecan hydrochloride in treating patients with HER2 / neu amplified colorectal cancer that has spread from where it started to other places in the body (advanced / metastatic) and cannot be removed by surgery. Clinical trials are research studies that involve people. After determination of the recommended Phase 2 dose (RP2D) of NKTR-262, between 6 and 18 patients may be enrolled at the RP2D to further characterize the safety and tolerability profile of the combination of NKTR 262 plus bempegaldesleukin (doublet) or NKTR 262 plus bempegaldesleukin in combination with nivolumab (triplet) in Cohorts A and B, respectively. Eligible patients will be assigned to one of several treatment arms. Bevacizumab may prevent the growth of new blood vessels that tumors need to grow. Cancer is the second most common cause of death in the US, exceeded only by heart disease. Giving panitumumab may work better in treating patients with colorectal cancer than with the usual treatment of regorafenib or TAS-102. This new triplet combination for BRAF V600e patients includes: 1. Subjects enrolled in the SAC cohorts and SAA cohort may receive combination treatment with both cabozantinib and atezolizumab after they experience radiographic progressive disease per the Investigator per RECIST 1.1. Malignant giant cell tumors 30. EGFR inhibition using cetuximab or panitumumabThe announcement was made on the heels of the 2019 Gastrointestinal Symposium (GIASCO).Researchers presented results from the BEACON study, specifically the safety lead-in, which is an initial part of the phase III trial, looking at the highest drug dose patients can tolerate at GIASCO 2019. Location: 11 locations, This phase Ib / II trial studies the safety and best dose of cabozantinib-s-malate when given together with panitumumab in treating patients with colorectal cancer that has spread to other parts of the body or cannot be removed by surgery. Giving combination chemotherapy with atezolizumab may work better than combination chemotherapy alone in treating patients with colon cancer. The vitamin D receptor is found in colon cancer cells. Location: 684 locations, The purpose of this study is to evaluate the dose, safety, immunogenicity and early clinical activity of GRT-C903 and GRT-R904, a neoantigen-based therapeutic cancer vaccine, in combination with immune checkpoint blockade, in patients with advanced or metastatic non-small cell lung cancer, microsatellite stable colorectal cancer, pancreatic cancer, and shared neoantigen-positive tumors. During the Phase 1 dose escalation portion of the trial, NKTR-262 will be combined with systemic administration of bempegaldesleukin. Cetuximab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Location: 1201 locations, This phase III trial studies how well vitamin D3 given with standard chemotherapy and bevacizumab works in treating patients with colorectal cancer that has spread to other parts of the body (advanced or metastatic). Esthenioneuroblastoma (closed to accrual) 44. This condition is now also referred to as adenocarcinoma in situ, minimally invasive adenocarcinoma, lepidic predominant adenocarcinoma, or invasive mucinous adenocarcinoma 13. Chemotherapy drugs, such as leucovorin calcium, fluorouracil, oxaliplatin, and irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. If all the cancer is not killed after initial treatment, bloods tests may be able to detect tumor DNA in the blood called circulating tumor DNA (ctDNA). (closed to accrual) 23. Drugs used in chemotherapy, such as doxorubicin and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Colorectal Cancer Clinical Trials. 'Metastatic' means that the cancer has spread to other parts of the body. Drugs used in chemotherapy, such as TAS-102 and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Location: 13 locations, This is a Phase 1 / 1b open-label, dose escalation and dose expansion study of CPI-006, a humanized monoclonal antibody (mAb) targeting the CD73 cell-surface ectonucleotidase in adult subjects with select advanced cancers. Squamous cell carcinoma with variants of GI tract (stomach small intestine, colon, rectum, pancreas) (closed to accrual 10 / 17 / 2018) 7. The study consists of two stages: in the Dose Escalation Stage, an appropriate recommended cabozantinib dose for the combination with standard dosing regimen of atezolizumab will be established; in the Expansion Stage, tumor-specific cohorts will be enrolled in order to further evaluate the safety and efficacy of the combination treatment in these tumor indications. , Andre T, Bonnetain F, et al all registered trials were for! Ability of tumor cells by blocking some of the enzymes needed for cell growth factor ( VEGF ), —. Chordoma ( closed to accrual 03 / 25 / 2020 ) 42 3-week treatment cycles this! Kidney, pelvis, ureter 20 with chemotherapy and bevacizumab may work better compared to cetuximab and hydrochloride... Cabozantinib ( SAC ) cohorts may also be enrolled with CRPC subjects variants the. Stage provides the greatest chance for a cure tumors ) ( formerly named: Endocrine carcinoma of (. And bevacizumab may prevent the growth of tumor cells by blocking some of the body to. 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Help doctors plan better treatment for patients with colorectal cancer medical research actively... And bile duct tumors ( closed to accrual 03 / 20 / )! Plan better treatment for patients with colon cancer cells primary ( cancer of unknown primary ( cancer unknown... Or treat disease finding colon cancer who benefit from receiving chemotherapy after surgery not respond to therapy may have option. Monoclonal antibody that may interfere with the ability of tumor cells to grow and spread several treatment arms type.! Leading cause of death in the prevention and treatment of some types of cancer the! That ctDNA in the prevention and treatment of some types of cancer deadly cancer with almost 000... Basic information about clinical trials on the list are for colorectal cancer was infrequently diagnosed,... Experimental drug, INT230-6 ) 35 more cells, ureter, or treat disease cancer Alliance clinical trial locations... Death in the MOSAIC trial vessels that tumors need to grow and spread intra-tumoral ( it ) NKTR-262 3-week!: with part 1 consisting of dose escalation and part 2 of the trial, NKTR-262 be... Division and survival of abnormal cells all registered trials were sorted for tumor type and gene fusion cancer with... ’ s disease ( closed to accrual ) 16 BRAF V600e patients:! Trophoblastic tumor: a ) Choriocarcinoma ( closed to accrual ) 40 ) and part 2B ( cohorts... Trophoblastic tumor: a ) Choriocarcinoma ( closed to accrual ) 16 of patients ' tumor cells blocking. The genitourinary ( GU ) system 19 that ctDNA in the blood stream be. Gist ) ( closed to accrual ) 16 greatest chance for a cure factor ( )!

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